CD57 NK Cell Count

Diagnostic Tests for CD57 NK Cell Count

The CD57 marker is present on natural killer cells (NK) and T lymphocytes. In cases of chronic diseases, including Lyme disease, the number of CD57 NK cells has been shown to be below normal. Following treatment, the count can return to normal (Stricker and Winger, 2001. Immunol Letter. 76:43-48). However, the utility of this test is controversial. Marques et. al. (2009 Clin. Vaccine Immunol. 16:1249-50) reported that there was no difference between the CD57 NK cell counts among patients with Lyme disease and normal controls. This test measures only the CD57 NK cells and may be useful for patients with known Lyme disease who present with chronic symptoms. If the count is low, the cause of the symptoms may be from Borrelia burgdorferi. If the count is normal, the cause may still be from Lyme disease, but it could also be due to some other agent.

CD57 NK Cell Test

Test Number: 275
CPT Code: 86356
Methodology:  Flow Cytometry

 

Reference Range

CD57 NK Cells (Absolute Count/µl)
<40
LOW
40 to 98
BORDERLINE
98
NORMAL

 

CD57 NK Cells (Absolute Count/µl)
<2.26
LOW
2.26 to 4.65
BORDERLINE
>4.65
NORMAL

Clinical Significance

The CD57 is expressed on both natural killer (NK) cells and T lymphocytes.   The CD57 test measures CD57 positive NK cells only. The test is performed on EDTA whole blood. In patients with low CD 57 counts, Lyme disease and Chlamydophila pneumoniae infections should be included in differential diagnosis.

Limitations: 

If laboratory tests are positive for Lyme disease in a chronically ill patient, this test can be useful prior to antimicrobial therapy to suggest that the cause of the symptoms is due to Lyme disease. If the count is low, repeat testing after therapy can also be useful.

FOR HEALTHCARE PROFESSIONAL:
Physicians may want to consider having a patient’s blood tested for other possible causes of symptoms, including Lyme disease and other tick-borne infections.

Disclaimer:  This test was developed and its performance characteristics determined by IGeneX, Inc. It has not been cleared or approved by the FDA. The FDA has determined that such approval is not necessary. This test is used for clinical purposes and should not be regarded as investigational or for research. IGeneX Inc. is licensed by CMS and NYS to perform high complexity clinical laboratory testing.

Clinical Significance

The CD57 is expressed on both natural killer (NK) cells and T lymphocytes.   The CD57 test measures CD57 positive NK cells only. The test is performed on EDTA whole blood.  In patients with low CD 57 counts, Lyme disease and Chlamydophila pneumoniae infections should be included in differential diagnosis.

Limitations: 

If laboratory tests are positive for Lyme disease in a chronically ill patient, this test can be useful prior to antimicrobial therapy, to suggest that the cause of the symptoms is due to Lyme disease.  If the count is low, repeat testing after therapy can also be useful.

FOR HEALTHCARE PROFESSIONALS:
Physicians may want to consider having blood tested for other possible causes of their patient’s symptoms, including other tick-borne infections, such as Lyme disease.

Disclaimer:  This test was developed and its performance characteristics determined by IGeneX, Inc. It has not been cleared or approved by the FDA. The FDA has determined that such approval is not necessary. This test is used for clinical purposes and should not be regarded as investigational or for research. IGeneX Inc. is licensed by CMS and NYS to perform high complexity clinical laboratory testing.

 

 

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Collection Kits

Compatible with Samples Other than Blood or Urine

Misc. Collection Kit

The Miscellaneous Collection Kit is compatible with tick-borne disease tests that require samples other than blood or urine, such as cerebral spinal fluid (CSF), tissue, placenta or breast milk.

Compatible with All Tests that Require Blood

Blood Collection Kit

The Blood Collection Kit is compatible with most of the tick-borne disease tests and panels. The panels are usually the most comprehensive available for testing for Borreliosis/Lyme disease as well as co-infection(s) with other tick-borne illnesses.

Compatible with All Tests that Require Urine

Urine Collection Kit

The Urine Collection Kit is compatible with all tick-borne disease tests that require urine samples. These tests are particularly useful during the acute phase of a tick-borne disease infection before antibodies are present as well as for seronegative patients, patients with vague symptoms of long duration, and previously-treated patients with recurring symptoms.

Receipt of payment for the testing and a signed Requisition Form is required upon submission of patient's test specimen to IGeneX, with the exception of Medicare patients.